P-27/ BO-04 : Risk Prediction of Acute Coronary Syndrome by Circulating sTLT1 level in Indian subpopulation

posted Jan 26, 2017, 6:28 AM by sourav ghosh   [ updated Jan 26, 2017, 6:34 AM ]

Apabrita Ayan DasTanima BanerjeeDr.Praksh Chandra MandalDr. Arun Bandyopadhyay
CSIR-Indian Institute of Chemical Biology, Kolkata, India

Soluble TREM like transcript 1(sTLT1) is reported to be associated with inflammation and major processes related to atherosclerosis. This study aimed to examine the expression of sTLT1 in normal and patient population as well as to evaluate its prognostic significance. Here, ELISA and Western blot analysis were performed to check expression of sTLT1 in study groups. The results showed that sTLT1 expression was significantly higher in ACS patients and asymptomatic population than control population (p<0.05).Moreover, correlation studies showed that sTLT1 level was not only associated with common ACS risk factors in both patient and asymptomatic group but also correlated with disease severity (LVEF, GRACE and TIMI score). Further correlation studies on sTLT1 level and total atherosclerotic burden (tunica intima-tunica media thickness) indicated a significant relation between these two variables pointing the potential of this protein as a risk predictor. ROC curve analysis for both the groups showed that sTLT1 had two definite cut off values for two separate study populations with better sensitivity and specificity. Lastly, logistic regression analysis against the risk factors showed it can act as an independent risk predictor in both patient and normal population respectively.