Growing 3D hearts: A perspective on organoids for translational research

posted Jan 25, 2017, 10:34 PM by sourav ghosh
Debojyoti Chakraborty
CSIR-Institute of Genomics & Integrative Biology, New Delhi, India

The field of regenerative medicine has experienced a rapid boost since the development of mini organs in the lab, also known as organoids. These miniature organs have paved the way for studying models of development and establishment of platforms for personalized medicine. Growing cardiac organoids is a relatively new area of research and offers exciting avenues for modelling heart disorders. Current technologies allow organoid development from cells originating from the organ or from reprogrammed induced pluripotent stem cells (iPSCs), the latter being a powerful tool for personalized therapies. Combining bioengineering techniques for providing optimal scaffolds to efficient methods of organoid development, scientists are currently striving to utilise organoids for solving complex disease pathways and modelling developmental programmes.