Genetics of Type 2 Diabetes in India: Association to causality

posted Jan 26, 2017, 3:11 AM by sourav ghosh   [ updated Jan 26, 2017, 3:12 AM ]
Dwaipayan Bharadwaj
1 Systems Genomics Laboratory, School of Biotechnology, Jawaharlal Nehru University, New Delhi, 2 CSIR-Institute of Genomics & Integrative Biology, New Delhi, India

The rapid increase in the prevalence of type 2 diabetes in the 21st century has earned it’s name as a global epidemic, affecting over 347 million people worldwide. Several risk factors for T2D including age, sex, obesity, low physical activity, smoking and diet have already been identified. Exploring the hereditary components of T2D has been highlighted by several research groups till date, majorly involving genome wide association studies to find the causal route to this disease. Our lab at CSIR-IGIB has carried out a type 2 diabetes GWAS in Indian population, taking about 12,535 human samples under consideration. We found five novel signals at the 2q21 position of human genome within TMEM163 gene that encodes for a synaptic vesicular membrane protein.Further experimentations are being done in order to find out the biological role of TMEM163 with respect to T2D etiology.

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