The impact of lower vitamin D metabolites levels on coronary artery disease in type 2 diabetes patients in India

posted Jan 26, 2017, 1:05 AM by sourav ghosh
Sanjay K Banerjee
Drug Discovery Research Center, Translational Health Science and Technology Institute, Faridabad, India

The association of vitamin D insufficiency and increased risk of metabolic diseases has been reported in several scientific journals. However, it is not clear which vitamin D metabolite should be measured and the association of each metabolite with increased risk of metabolic diseases. Among all vitamin D metabolites, only 25(OH)D and 1,25(OH)2D have received great attention. Hence in the present study six vitamin D (D2/D3) metabolites have been quantified by LC-MS method. The purpose of the present study is to measure six vitamin D metabolites, total 25(OH)D and total 1,25(OH)2D levels and to find the association between vitamin D deficiency and coronary artery diseases in diabetes. Four groups [control, type 2 diabetes (T2DM), coronary artery diseases (CAD), T2DM with CAD (T2DM_CAD)] were included for the study. Glycated hemoglobin (HbA1c) and fasting blood sugar (FBS) levels were increased significantly (p < 0.05) in patients having 20–30 ng/ml and <20 ng/ml at 25(OH)D levels as compared with subjects having >30 ng/ml of 25(OH)D. Our data revealed that all the vitamin D metabolites were significantly (p < 0.05) decreased in T2DM_CAD as compared to both control and T2DM subjects. However, only two metabolites i.e., 25(OH)D3 and total 25(OH)D were significantly (p < 0.05) decreased in the T2DM subjects as compared with the control subjects. Multiple logistic regression analysis revealed that total 25(OH)D and total 1,25(OH)2D can be used to predict T2DM and T2DM with CAD respectively. This study concludes that lower vitamin D metabolites levels is associated with type 2 diabetes coexisting with coronary artery diseases in Indian subjects.